Development of a 3D cell culture system based on a microfluidic platform
نویسندگان
چکیده
منابع مشابه
Development of a Microfluidic Hanging Droplet Platform for 3d Cell Culture
This paper reports a method for the automatic generation of hanging drops (HDs) for sustained three-dimensional (3D) cell culture. HDs emerge automatically through openings at the bottom of a microfluidic channel, which provides a means of and control over the mass transport into and out of the HD. We demonstrated the automatic formation of an array of HDs of various sizes using a microfluidic ...
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چکیده ندارد.
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Clinically relevant studies of cell function in vitro require a physiologically-representative microenvironment possessing aspects such as a 3D extracellular matrix (ECM) and controlled biochemical and biophysical parameters. A polydimethylsiloxane (PDMS) microfluidic system with a 3D collagen gel has previously served for analysis of factors inducing different responses of cells in a 3D microe...
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Biochemical gradients are ubiquitous in biology. At the tissue level, they dictate differentiation patterning or cell migration. Recapitulating in vitro the complexity of such concentration profiles with great spatial and dynamic control is crucial in order to understand the underlying mechanisms of biological phenomena. Here, a microfluidic design capable of generating diffusion-driven, simult...
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We introduce the first lab-on-a-chip platform for complete mammalian cell culture. The new method is powered by digital microfluidics (DMF), a technique in which nanolitre-sized droplets are manipulated on an open surface of an array of electrodes. This is the first application of DMF to adherent cell culture and analysis, and more importantly, represents the first microfluidic platform capable...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2018
ISSN: 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00050